The global supply chain landscape in 2025 is characterized by unprecedented volatility, driven by geopolitical shifts, energy price fluctuations, and rapid technological disruptions. This research investigates the causal relationships between Cross-Functional Integration (CFI), Supply Chain Partnership (SCP), Supply Chain Responsiveness (SCR), Supply Chain Resilience (SCRes), and their collective impact on the Competitive Advantage (CA) of supply chain-dependent industries in Thailand. As Thailand transitions towards high-value manufacturing in sectors such as Electric Vehicles (EVs), electronics, and food processing, the ability to withstand systemic shocks while maintaining operational efficiency is paramount. Employing a mixed-method research design, the study utilizes quantitative data gathered from 400 executives across these key industrial sectors, analyzed via Structural Equation Modeling (SEM) to test the proposed hypotheses. Complementary qualitative insights are derived from in-depth interviews with 15 industry experts, including policymakers and senior executives, to validate the structural model and provide context-rich interpretations. The findings aim to provide a robust, empirically backed framework for Thai enterprises, positing that internal cross-functional integration serves as the critical antecedent that enables effective external partnerships and subsequent resilience. This study contributes to the strategic management literature by offering a localized model for elevating Thailand’s industrial competitiveness in an era of uncertainty.